In which of the following organs is prilocaine biotransformed?

Prilocaine is biotransformed primarily in both the liver and the lungs. The liver plays a key role in breaking down many medications, including prilocaine, through various enzymatic processes. In this context, certain enzymes are responsible for converting prilocaine into its active metabolites. Furthermore, the lungs also contribute to the metabolism of prilocaine, particularly due to their large surface area and the extensive blood supply they receive, which can facilitate the breakdown of the drug as it circulates through the body.

This dual site of metabolism is important because it impacts the pharmacokinetics of prilocaine, influencing factors such as its onset, duration of action, and potential side effects. Recognizing that both the liver and lungs are integral to the metabolism of prilocaine helps in understanding how the body processes local anesthetics and the importance of these organs in drug efficacy and safety.