Which of the following is related to early signs of local anesthetic toxicity?

CNS excitation is recognized as one of the initial signs of local anesthetic toxicity. When local anesthetics enter the systemic circulation, they can affect the central nervous system (CNS). Initially, as the drug begins to exert its effects, patients may experience symptoms of excitation, which can include symptoms like restlessness, agitation, increased heart rate, and tremors. This excitation phase is the body's response to the anesthetic's impact on neuronal excitability.

Monitoring for these early signs is crucial for timely intervention before more severe toxic effects, such as CNS depression, cardiovascular complications, or respiratory issues, develop. Therefore, identifying CNS excitation can serve as an important warning sign that local anesthetic levels may be reaching a dangerous threshold, necessitating immediate clinical attention.